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BrandsLSD breakthrough could enable treatment for autism and social anxiety, research finds
11.12.2022
The mechanism that enables the drug to stimulate sociability could be used to treat anxiety and autism spectrum disorders.
Researchers have discovered the mechanism that contributes to the hallucinogenic drug LSD increasing social interactions, potentially unlocking new therapeutic applications.
Lysergic Acid Diethylamide (LSD) became a popular psychedelic drug during the 1960s and is again gaining in popularity, with some young professionals claiming to take micro-doses to enhance their creativity.
Despite rigorous analysis and experimentation, including in the CIA's illegal MKUltra project during the 1950s, scientists have not been able to determine the mechanism of how LSD acts upon the brain - until now.
Researchers from McGill University in Canada have discovered that LSD activates the serotonin 5-HT2A receptors and AMPHA receptors in the brain, both of which combine to promote social interaction.
In their study, published in the journal PNAS, the scientists administered a low dose of LSD to mice over a period of seven days and discovered it resulted in an observable increase in their sociability.
Although the behaviour in mice is not directly equivalent with that in humans, with the researchers noting that it was largely analogous to empathy and social behaviour, the main outcome was identifying the underlying mechanism for the behavioural effect.
"The fact that LSD binds the 5-HT2A receptor was previously known," said Professor Nahum Sonenberg of McGill's department of biochemistry, co-author of the report.
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